Creative Multidisciplinary Engineering Lab

We are a multi-disciplinary laboratory aiming to uncover the mechanisms of exocytosis proteins in the pathogenesis of age-related disorders

OUR PUBLICATIONS

A Targeted Approach

The research in the lab aims to uncover the cellular and molecular mechanisms of secretory proteins behind diabetes and neurodegenerative diseases and engineer therapies that can stop or reverse the disease’s progression. We developed artificial suspended lipid bilayer platforms and single-molecule imaging methods to quantitively dissect the role of exocytosis proteins, SNAREs and their regulators, in type 2 diabetes and Alzheimer’s Disease.

  • Suspended Lipid Membrane
  • Lab-on-Chip
  • AI-driven Image Analysis

Join Us

We’re always looking for smart and enthusiastic people interested in joining the lab. Possible openings might be available for Ph.D. students and post-doc researchers.

If you think you might be interested in joining us, feel free to contact via email at
sathish.ramakrishnan@yale.edu

Recent Publications

  1. Kalyanasundaram RV, Bera M, Coleman J, Weerakkody JS, Krishnakumar SS, Ramakrishnan S.* “Native Planar Asymmetric Suspended Membrane for Single-Molecule Investigations: Plasma Membrane on a Chip” Small, 2022 (Cover article)
  2. Ramakrishnan S,* Weerakkody JS. “Suspended Lipid Bilayer: A Versatile Platform for Nextgen Drug Discovery and Biomedical Applications” ACS, Accounts of Materials Research, 2022 , (Cover article)

More Publications >>

“We are always on the lookout for enthusiastic, talented people from a wide range of backgrounds, including engineering, molecular cell biology, biophysics, computer science and neuroscience.” You can also check out our research page for more information about exciting projects in the lab. If you are excited about something having to do with lab-on-chip, odds are, we are too!

Join Us