We are a multi-disciplinary laboratory aiming to uncover the mechanisms of exocytosis proteins in the pathogenesis of age-related disorders

OUR RESEARCH
OUR PUBLICATIONS
OUR PUBLICATIONS
OUR RESEARCH

A Targeted Approach

The research in the lab aims to uncover the cellular and molecular mechanisms behind diabetes and neurodegenerative diseases and engineer therapies that can stop or reverse the disease’s progression. We developed artificial suspended lipid bilayer platforms and single-molecule imaging methods to quantitively dissect the role of exocytosis proteins, SNAREs and their regulators, in type 2 diabetes and Alzheimer’s Disease. Understanding the key players of exocytosis can drive therapeutic discovery by clarifying which proteins are critical for each step in the pathway.

  • Suspended Lipid Membrane – Native Cell Membrane on a Chip

  • microFACS – FACS on a chip

  • Data Science – AI-driven image analysis research

OUR RESEARCH

We’re always looking for smart and enthusiastic people interested in joining the lab. Possible openings might be available for Ph.D. students and post-doc researchers.

If you think you might be interested in joining us, feel free to contact via email at
sathish.ramakrishnan@yale.edu

Synapse on a chip

Our research focuses on building an artificial synapse on a chip to understand neuronal communication and dysfunction using MEMS and microTAS technologies to perform high-throughput screening and analysis.

Manipulating nanometric size vesicles

We are developing holographic-based FACS on a chip technology to understand cells and nanometer-sized vesicles heterogenity.

Organ on a Chip

We are developing microphysiological systems that can be used to grow engineered tissue models of different organs to recreate human disease models than using animals.